[H](+)S 14297: A novel, selective radioligand at cloned human dopamine D3 receptors |
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Authors: | A. Newman-Tancredi V. Audinot V. Jacques J. L. Peglion M. J. Millan |
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Affiliation: | Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, Paris, France |
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Abstract: | The selective dopamine D3 receptor antagonist [3H](+)S 14297 ((+)-[7-(N,N-dipropylamino)-5,6,7,8-tetrahydro-naphtho(2,3b)dihydro,2,3-furane]), labelled to high specific activity (145 Ci/mmol), bound to cloned human dopamine D3 receptors but displayed negligible binding to cloned human D2 receptors. [3H](+)S 14297 exhibited rapid association and dissociation, high affinity saturable binding (Kd = 7.0 nM) and a competition binding profile highly correlated with that of [125I]iodosulpride (r = 0.98). |
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Keywords: | Dopamine D3 receptor binding [3H](+)S 14297 Chinese hamster ovary (CHO) iodosulpride |
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