Bcl-2蛋白家族作用机制及其抑制剂的研究

综述了Bcl-2蛋白家族成员的结构、作用机制模式及抑制剂，特别是小分子抑制剂的研究进展。凋亡对于调节多细胞生物的个体发育和体内平衡具有重要作用，其异常可导致许多疾病的发生，而Bcl-2蛋白家族在凋亡通路中起重要的调节作用，它们与肿瘤的产生及耐药非常相关，可能成为抗肿瘤药物的新靶点。近几年研究者对它们的抑制剂也进行了初步研究。

Progress in Mechanisms and Inhibitors of Bcl-2 Protein Family

Apoptosis is essential in multicellular organisms, where it regulates development and homeostasis. The deregulation of apoptosis can result in a number of diseases, such as cancers which are caused by inhibition of apoptosis. Bcl-2 protein family plays an important role in the regulation of apoptosis and are relative to the tumorgenesis and muti-drug resistance, so they may be a new target of anticancer drugs. In recent years, the inhibitors of Bcl-2 protein family have been preliminarily studied. The progress in structure, mechanisms and inhibitors of Bcl-2 protein family was reviewed.