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| 上海地区鼻咽癌患者血清EB病毒抗体检测结果分析 | |
| 引用本文： | 王朱健,曹文俊,陈浮,沈健,汤荔,王胜资.上海地区鼻咽癌患者血清EB病毒抗体检测结果分析[J].中国眼耳鼻喉科杂志,2012,12(1):40-41,46. |
| 作者姓名： | 王朱健 曹文俊 陈浮 沈健 汤荔 王胜资 |
| 作者单位： | 1. 复旦大学生命科学学院遗传所 2. 复旦大学附属眼耳鼻喉科医院检验科 上海 200031 3. 复旦大学附属眼耳鼻喉科医院放疗科 上海 200031 |
| 基金项目： | 基金项目：复旦大学附属眼耳鼻喉科医院院级科研基金资助项目（EENT-2010-23、EENT-2009-21） |
| 摘 要： | 目的 评估EB病毒的Rta蛋白抗体(Rta/IgG)、核抗原抗体(EBNA1/IgA)和病毒衣壳抗原抗体(VCA/IgA)的检测对上海地区鼻咽癌患者的临床诊断价值.方法 收集206例病理证实未经治疗的鼻咽癌患者和249例健康成人的血清,均采用酶联免疫吸附试验法定量检测血清中的Rta/IgG、EBNA1/IgA、VCA/IgA抗体水平.结果 206例鼻咽癌患者的EB病毒抗体Rta/IgG、EBNA1/IgA、VCA/IgA的敏感度分别为64.08％、88.35％、86.89％；特异度分别为92.62％、92.92％、95.69％；3种抗体同时阳性的模式在鼻咽癌患者中出现的概率最高(55.83％),而在健康对照组中无一例出现.结论 Rta/IgG、EBNA1/IgA、VCA/IgA的联合检测对上海地区鼻咽癌患者的诊断具有参考价值.(中国眼耳鼻喉科杂志,2012,12:40-41,46) |
| 关 键 词： | 鼻咽癌 EB病毒 抗体 |
Analysis of serum anti-Epstein-Barr virus antibody in patients with nasopharyngeal carcinoma in Shanghai |
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| WANG Zhu-jian , CAO Wen-jun , CHEN Fu , SHEN Jian , TANG Li , WANG Sheng-zi.Analysis of serum anti-Epstein-Barr virus antibody in patients with nasopharyngeal carcinoma in Shanghai[J].Chinese Journal of Ophthalmology and otorhinolaryngology,2012,12(1):40-41,46. | |
| Authors: | WANG Zhu-jian CAO Wen-jun CHEN Fu SHEN Jian TANG Li WANG Sheng-zi |
| Institution: | . Clinical Laboratory, Eye Ear Nose and Throat Hospital, Fudan University,Shanghai 200031, China Corresponding author： CAO Wen-jun, Email ： caowenj @ yahoo, com. cn |
| Abstract: | Objective To evaluate the clinical value of Rta/IgG,EBNA1/IgA and VCA/IgA for nasopharyngeal carcinoma patients in Shanghai. Methods Rta/IgG, EBNA1/IgA and VCA/IgA was detected by quantitative enzyme- linked immunosorbent assay in 206 NPC patients and 249 healthy adults. Results The sensitivity rates were 64.08%, 88.35% and 86.89% for Rta/IgG,EBNA1/IgA and VCA/IgA respectively, while the specificity rates were 92. 62%, 92.92% and 95.69% respectively. The results were most common in NPC patients that all three antibodies were posi- tive,but none positive antibodies were seen in healthy adults. Conclusions The combined detection of Rta/IgG, EB- NA1/IgA and VCA/IgA has referential value in diagnosing nasopharyngeal carcinoma patients in Shanghai. （ Chin J Oph- thalmol and Otorhinolaryngo1,2012,12：40-41,46） |
| Keywords: | nasopharyngeal carcinoma Epstein-Barr virus Antibody |
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