| MUC4蛋白在口腔疣状癌表达的免疫组化研究 |
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| 引用本文： | 陈晓明,全宏志,唐瞻贵,刘友良,张清,易平良,李立国,方晓明,曾凡. MUC4蛋白在口腔疣状癌表达的免疫组化研究[J]. 陕西肿瘤医学, 2012, 0(4): 682-686 |
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| 作者姓名： | 陈晓明 全宏志 唐瞻贵 刘友良 张清 易平良 李立国 方晓明 曾凡 |
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| 作者单位： | [1]益阳医学高等专科学校口腔医学系,湖南益阳413001 [2]中南大学湘雅医院,口腔医学院,湖南长沙410008 |
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| 基金项目： | 湖南省教育厅科学研究项目（编号：10c0317） |
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| 摘 要： | 目的：研究MUC 4在口腔疣状癌的表达情况,探讨其在口腔疣状癌发生发展中的作用。方法：采用免疫组织化学方法,对18例口腔疣状癌、26口腔鳞癌和14例正常口腔黏膜MUC 4蛋白进行检测,并与临床病理参数比较。结果：口腔疣状癌和鳞癌组织中MUC 4蛋白表达显著高于正常黏膜（P〈0.05）,不同临床类型口腔疣状癌的蛋白表达无显著差异（P〉0.05）;MUC 4蛋白的表达与性别、年龄、发病部位、临床分期无显著相关（P〉0.05）。结论：口腔疣状癌和鳞癌中MUC 4蛋白呈上调表达,蛋白的表达可能与肿瘤的恶性程度相关。
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| 关 键 词： | 口腔疣状癌 MUC4 免疫组织化学 |
The immunohistochemistry study on the expression of MUC 4 in oral verrucous carcinoma |
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| CHEN Xiaoming,QUAN Hongzhi,TANG Zhangui,LIU Youliang,ZHANG Qing,YI Pingliang,LI Liguo,FANG Xiaoming,ZENG Fan. The immunohistochemistry study on the expression of MUC 4 in oral verrucous carcinoma[J]. Shaanxi Oncology Medicine, 2012, 0(4): 682-686 |
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| Authors: | CHEN Xiaoming QUAN Hongzhi TANG Zhangui LIU Youliang ZHANG Qing YI Pingliang LI Liguo FANG Xiaoming ZENG Fan |
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| Affiliation: | 1Yiyang Medical College,Hunan Province Yiyang 413001,China;2Xiangya Hospital,School of Stomatology,Central South University,Hunan Changsha 410008,China. |
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| Abstract: | Objective：To study the expression of MUC 4 in oral verrucous carcinoma（OVC）,and its role in the development of OVC.Methods： By immunohistochemistry,MUC 4 protein expression was studied in 18 OVCs,oral squamous carcinomas（OSCC） and 14 normal mucosas（NM）,and the relation between protein expression and clinopathologic features was studied.Results： MUC 4 protein in OVC/OSCC was significantly higher than NM（P0.05）,no significant difference was found among different types of tumor（P0.05）.Conclusion： MUC 4 protein was up-expressed in OVC and OSCC,it may take part in the development of tumor. |
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| Keywords: | oral verrucous carcinoma MUC 4 immunohistochemistry |
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