抗结核病药物短程化疗致肝功能损害180例

目的 观察抗结核药物短程化疗对肝功能的损害情况.方法 180例初治肺结核患者在SHRZ方案化疗中不分年龄,不分痰涂阴阳,入院时肝功能正常,均列入短程化疗组,观察丙氨酸氨基转移酶（ALT）与天门冬氨酸氨基转移酶（AST）的变化情况.结果 化疗中肝损伤率迭41.11%,其中患者受损比例乙型肝炎病毒标志物（HBVM）阳性组为59.25%,HBVM阴性组为32.75%（P＜0.05）;肝功能受损男性占51.43%,女性占9.54%（P＜0.01）.结论 制订化疗方案之前应了解病史,特别是与肝脏受损程度有关的疾病,以便短程化疗能顺利完成.

Liver Damage Caused by Short-period Antituberculotic Chemical Treatment in 180 Cases

Objective To observe the liver damage by antituberculotic in the short-period treatment.Methods In the SHRZ chemical treatment,the 180 first-treating patients with pulmonary tuberculosis and normal liver function were put into the observing group of the short-period chemical treatment regardless of their ages and amount of expectoration.The changes of ALT and AST were observed.Results In the chemical treatment,the rate of liver damage reached 41.11% .In it,the rate of liver damage was 59.25% for the patients whose HBVM was positive and that was 32.75% for the patients whose HBVM was negative (P < 0.05),and the rate of liver damage for male was 51.43% and that for female was 9.54% (P < 0.01).Conclusion Before taking the chemical treatment,learning the medical history of patients,especially about the liver diseases,can guarantee the short-period treatment successfully.