The Therapeutic Potential of T Cell Metabolism |
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Authors: | A. Zarrinpar S. J. Bensinger |
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Affiliation: | 1. Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA;2. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA;3. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA |
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Abstract: | Transplant rejection mediated by the adaptive immune system remains a major barrier to achieving long‐term tolerance and graft survival. Emerging evidence indicates that lymphocytes rapidly shift their metabolic programs in response to activation, co‐stimulatory, and cytokine signals to support required effector cell differentiation and function. These observations have led to the hypothesis that manipulating the metabolic programs of immune cells could serve as a powerful therapeutic strategy for attenuating deleterious immune responses and facilitating durable tolerance in the setting of allogeneic solid organ or bone marrow transplant. In this mini‐review, we introduce the fundamentals of metabolism, highlight the current understanding of how adaptive immune cells utilize their metabolic programs, and discuss the potential for targeting metabolism as a therapeutic approach to induce tolerance in the transplant setting. |
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Keywords: | basic (laboratory) research/science translational research/science immunobiology immunosuppression/immune modulation molecular biology immune regulation metabolism/metabolite T cell biology |
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