| 核素氯化^89锶对多发性骨转移瘤患者细胞免疫状态的影响 |
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| 引用本文： | 吴永刚,马琦琳,等.核素氯化^89锶对多发性骨转移瘤患者细胞免疫状态的影响[J].湖南医科大学学报,2002,27(3):277-278. |
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| 作者姓名： | 吴永刚 马琦琳 |
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| 作者单位： | [1]中南大学湘雅二医院核医学科，长沙410011 [2]中南大学湘雅医院心内科，长沙410007 |
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| 摘 要： | 目的：探讨氯化^89锶（^89Sr)治疗对多发性骨转移瘤患者免疫状态的影响。方法：采用^89Sr内照射治疗多发性骨转移瘤患者，测定治疗前后患者的血T细胞亚群、NK细胞活性以及淋巴细胞转化率。结果：^89Sr治疗多发性骨转移瘤疼痛缓解组T细胞亚群改善，NK细胞活性上升，淋巴细胞转化率升高；疼痛未缓解组，其各指标无明显变化。结论：^89Sr治疗骨转移瘤可一定程度的改善患者细胞免疫功能。
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| 关 键 词： | 核素氯化^89锶 多发性骨转移瘤 细胞免疫状态 影响 NK细胞活性 |
Influence of 89Sr on the cell immune function in patients with multiple bone metastases] |
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| Yong-gang Wu,Qi-lin Ma,Guo-feng Liu.Influence of 89Sr on the cell immune function in patients with multiple bone metastases][J].Bulletin of Hunan Medical University,2002,27(3):277-278. |
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| Authors: | Yong-gang Wu Qi-lin Ma Guo-feng Liu |
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| Institution: | Department of Nuclear Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China. |
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| Abstract: | OBJECTIVE: To investigate the influence of 89Sr on the cell immune function in patients with multiple bone metastases. METHODS: Patients with multiple bone metastases were treated with in vivo radiation of 89Sr. The T cell subsets, NK cell activities, and lymphocyte transformation rate (LTR) of multiple bone metastases before and after the 89Sr treatment were measured. RESULTS: With the palliation of the pain of the patients after the 89Sr treatment, the T cell subset level, NK cell activities, and LTR increased. There was no significant change in the patients with the pain. CONCLUSION: Treating multiple bone metastases with 89Sr can improve the cell immune function of the patients to a certain extent. |
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