CT在视网膜母细胞瘤钙化研究中的价值

目的通过CT检查及图像后处理软件,分析视网膜母细胞瘤(RB)内钙化程度与性别、眼别、年龄、影像学分期之间的关系。方法选择经河北省眼科医院眼眶病及眼肿瘤科手术或穿刺病理证实的120例RB患者150眼进行研究。通过影像学分期将其分为4组:眼球内期组98眼,其中肿瘤内钙化87眼;青光眼期组37眼,其中肿瘤内钙化34眼;眼球外期组11眼,其中肿瘤内钙化10眼;远处转移期组4眼,其中肿瘤内钙化3眼。眼眶横断面CT薄层扫描、软组织算法重建,采用西门子Volume软件测量钙化区域容积及眼球容积。使用SPSS 22.0统计分析软件处理实验数据,分析不同性别、眼别、年龄、影像学分期间钙化区域容积(CRV)/眼球容积(EV)比值采用秩和检验。结果眼球内期组不同性别、眼别RB患者CRV/EV比值差异无统计学意义;眼球内期组RB患者不同年龄组间CRV/EV比值差异有统计学意义;两两比较后显示1岁~组肿瘤钙化程度低于2岁~组,1岁~组肿瘤钙化程度低于3岁~组,1岁~组肿瘤钙化程度低于0岁~组;青光眼期组不同性别RB患者CRV/EV比值之间进行比较,差异有统计学意义,女性高于男性;青光眼期组不同眼别RB患者CRV/EV比值进行比较,差异有统计学意义,右眼高于左眼;青光眼期组不同年龄组间RB患者CRV/EV比值进行比较,差异无统计学意义;眼球内期组与青光眼期组RB患者CRV/EV比值期别进行比较,差异有统计学意义,RB患者青光眼期肿瘤钙化程度高于眼球内期。结论RB患者钙化程度在眼球内期、青光眼期随病情进展呈上升趋势;眼球内期RB患者1岁~组肿瘤钙化程度出现低谷区。

The value of CT in the study of calcification in retinoblastoma

Objective To find the correlation among patients′gender,eye identify,medical imaging grade,calcification in retinoblastoma(RB)patients by using CT examination and image post-processing software.Methods General information and grouping-120 RB patients cases(150 eyes),who were diagnosed by pathological examinations in Hebei Provincial Eye Hospital were included in the current study from September 2009 to October 2015.According to its imaging staging,they were divided into four groups:intraocular stage group(98 eyes in total with tumor calcification in 87 eyes),glaucoma stage group(37 eyes in total with tumor calcification in 34 eyes),extraocular stage group(11 eyes in total with tumor calcification in 10 eyes),and distant metastases stage group(4 eyes in total tumor with calcification in 3 eyes).CT scanning and data post-processing-orbital cross-sectional CT thin scanning,soft-tissue algorithm reconstruction,calcification volume and ocular volume were measured by Siemens Volume software.The data was analyzed by SPSS 22.0 Software.The CRV/EV among gender,right/left eyes,age,medical image stages were analyzed using rank-sum test.Results No statistical difference in CRV/EV was found in different gender and eyes in intraocular stage group.Statistical difference in CRV/EV was found in different age groups of intraocular stage group.Using post hoc multiple comparisons,the calcification in one-year old patients were lower than two-year old patients;The calcification in one-year old patients was lower than three-year old patients;The calcification in one-year old patients were lower than zero-year old patients.There was statistical difference between male and female in glaucoma stage group;And also there was statistical difference between right and left eye sin glaucoma stage group;which right eyes are higher than left eyes.No statistical difference in CRV/EV was found among different ages in glaucoma stage groups.No statistical difference in CRV/EV was found between intraocular and glaucoma stage groups.Conclusion The calcification degree in RB patients was increasing when the patients were in intraocular and glaucoma stage.A low incidence of tumor calcification was found in one-year old patients in intraocular stage.