膀胱癌中环氧化酶-2的表达与临床病理的关系(英文)

目的　探讨环氧化酶 - 2 (COX - 2 )表达与膀胱癌生物学行为的关系及其意义。方法　采用免疫组化SABC法检测 5 4例膀胱癌、2 9例癌旁组织和 10例正常膀胱粘膜中的COX - 2表达 ,结合临床病理资料进行分析。结果　COX - 2在不同膀胱组织中的表达差异有显著性 (P <0 .0 5 ) ,即膀胱癌组织 >癌旁组织 >正常膀胱粘膜。COX - 2表达随膀胱癌病理级和临床分期的增加而增加 (P <0 .0 5、P <0 .0 1) ,且癌组织中COX - 2表达与淋巴转移有关 (P <0 .0 5 )。结论　COX - 2表达与膀胱癌病理分级、临床分期、淋巴转移有关 ,提示它可能在胱癌的发生、发展中扮演重要角色 ,通过抑制COX - 2活性可能为膀胱癌的防治提供新途径。

EXPRESSION OF CYCLOOXYGENASE-2 IN BLADDER CARCINOMA AND ITS RELATION TO CLINICAL-PATHOLOGY

Objective:To study the expression of cyclooxygenase-2(COX-2) and relationship with biological behavior of bladder cancer and its clinical significance.Methods:The immunohistochemical SABC method was used to determine the expression of COX-2 in 54 cases of bladder cancer, 29 cases of adjacent nontumorous and 10 cases of normal bladder specimens respectively.Results:The positive expression of COX-2 showed significant difference in different tissues of bladder (P<0.05), and was significantly higher in the cancer tissue.The intensity of COX-2 expression was increased with increasing pathological grades of tumor and clinical stage(P<0.05, P<0.01).There was significant correlation between the lymph node metastasis and expression of COX-2 of bladder carcinoma (P<0.05).Conclusions:The expression of COX-2 is related to the pathological grades, clinical stage, the lymph node metastasis of tumor. This result suggests that cyclooxygenase-2 may be play a role in the development and growth of bladder cancer, the inhibition of cyclooxygenase-2 development may give a new treatment for bladder cancer.