| 别嘌醇致严重肝损害 |
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| 引用本文： | 崔会娣,于桂兰,主理群. 别嘌醇致严重肝损害[J]. 药物不良反应杂志, 2008, 10(4): 288-288 |
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| 作者姓名： | 崔会娣 于桂兰 主理群 |
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| 作者单位： | 中国医学科学院北京协和医院卫干门诊,北京,100730 |
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| 摘 要： | 1例83岁女性，因发现血尿酸升高服用别嘌醇100mg／d治疗。2周后出现恶心，乏力，黄疸。实验室检查示：AIJT945U／L，AST1521U／L，TBil259．3μmol／L，DBil137．8μmol／L。甲、乙、丙、戊型肝炎血清学检测为阴性，考虑肝损害与别嘌醇有关，停用别嘌醇，并给予复方甘草酸苷等治疗，1个月后症状逐渐改善，肝功能恢复正常。
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| 关 键 词： | 别嘌醇 肝损害 不良反应 |
Severe liver damage associated with allopurinol |
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| Cui Huidi,Yu Guilan,Zhu Liqun. Severe liver damage associated with allopurinol[J]. Adverse Drug Reactions Journal, 2008, 10(4): 288-288 |
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| Authors: | Cui Huidi Yu Guilan Zhu Liqun |
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| Affiliation: | ( Cadre＇s Outpatient Clinic, Peking Union Medical College Hospital, Chinese Acade,ny of Medical Science, Beijing 100730, China) |
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| Abstract: | An 83-year-old woman with increased blood uric acid was administered with oral allopurinol 100 mg/day. Two weeks later, the woman developed nausea, asthenia and jaundice, Laboratory investigations revealed the following values ： ALT 945 U/L, AST I 521 U/L,TBil 259.3 μmol/L,DBil 137.8 μmol/L. Serologic tests for viral hepatitis A, B, C and E were negative. Liver damage associated with allopurinol was suspected. Allopurinol was discontinued, and compound glycyrrhizic acid glycoside was given. Her symptoms improved gradually one month later and her liver function returned to normal limits. |
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| Keywords: | allopurinol liver damage adverse reaction |
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