压力超负荷心肌肥厚过程中外周血CGRP NPY的变化

目的：探讨从心血管压力负荷增加到心肌肥厚形成的全过程中外周血神经肽-Y（NPY）、降钙素基因相关肽（CGRP）的变化及意义。方法：参照腹主动脉部分缩窄法制作压力负荷性心肌肥厚大鼠模型,采用放射性免疫法检测各组大鼠不同时间点外周血NPY和CGRP的浓度,电子天平称量左心室重,计算心重指数（LVW/BW）。结果：①模型组NPY的浓度高于对照组（P〈0.05）,与心重指数呈正相关;②模型组CGRP的浓度均低于对照组（P〈0.05）,与心重指数呈负相关。结论：血浆神经肽-Y、降钙素基因相关肽的浓度比例失衡参与了压力负荷增加致左心室肥厚的发生,二者在高血压左心室肥厚的发生、发展中具有不可忽视的作用。

NPY and CGRP Changes in the Whole Process of Over- Loaded Heart Hypertrophy

Objective：To investigate the significance of changes in peripheral blood neuropeptide Y（NPY） and calcitonin gene-related peptide（CGRP） from the increasing of load to hypertrophy.Methods： The partial abdominal aorta ligature was used to induce hypertrophy in rats.NPY and CGRP were determined with radioimmunological assay.The left ventricular weight was weighed with electronic balance.Result： Comparing with control rats,The level of NPY increased greatly in rats with ventricular hypertrophy.There was positive correlation of NPY with degree of left ventrical hypertrophy.Whereas the level of CGRP decreased greatly in rats with ventricular hypertrophy.There was negative correlation of CGRP with degree of left ventrical hypertrophy.Conclusion：The levels of plasma NPY and CGRP were related to LVH.The mechanism of heart failure might be related with the disorganization of NPY and CGRP levels in plasma so as the left ventricular hypertrophy.