| HPLC法测定抗病毒口服液中连翘苷的含量 |
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| 引用本文： | 左毅,李恒.HPLC法测定抗病毒口服液中连翘苷的含量[J].中国药师,2009,12(7):921-922. |
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| 作者姓名： | 左毅 李恒 |
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| 作者单位： | 武汉市药品检验所,武汉,430012 |
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| 摘 要： | 目的：建立HPLC法测定抗病毒口服液中连翘苷含量的方法。方法：色谱柱：ODS柱（150mm×4．6mm，5μm）；流动相：乙腈-水（25：75）；流速1．0ml·min^-1；检测波长：277nm；柱温：30℃。结果：连翘苷的浓度在20．34～406．80μg·ml^-1范围内与色谱峰面积呈良好线性关系（r=1．0000），平均回收率为98．52％，RSD=1．3％（n=6）。结论：本方法操作简便，结果准确，重复性好，可有效控制抗病毒口服液的质量。
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| 关 键 词： | 抗病毒口服液 连翘苷 HPLC |
Determination of Phillyrin in Kangbingdu Oral Solution by HPLC |
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| Zuo Yi,Li Heng.Determination of Phillyrin in Kangbingdu Oral Solution by HPLC[J].China Pharmacist,2009,12(7):921-922. |
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| Authors: | Zuo Yi Li Heng |
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| Institution: | ( Wuhan Institute for Drug Control ,Wuhan 430012 ,China) |
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| Abstract: | Objective： To establish a quantitative method for phillyrin in Kangbingdu oral solution by HPLC. Method： ODS column（ 150mm × 4.6mm,5 μm） was used. The mobile phase was composed of acetonitrile-water（ 25：75 ）. The flow rate was 1.0 ml· min^-1. The detection wavelength was set at 277nm. Column temperature was 30℃. Result： The linear range of phillyrin was 20.34 - 406.80μg·ml^-1 （ r = 1. 000 0）. The average recovery was 98.52% and RSD was 1.3% （ n = 6）. Conclusion： The method is convenient, aecurate, reprodueible and sensitive, which can be used to eontrol the quality of Kangbingdu oral solution. |
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| Keywords: | HPLC |
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