| 丹参酮对RBL-2H3肥大细胞增殖凋亡以及活化脱颗粒的影响 |
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| 引用本文： | 王文君,王培训,粱瑞燕. 丹参酮对RBL-2H3肥大细胞增殖凋亡以及活化脱颗粒的影响[J]. 现代免疫学, 2008, 28(2): 132-135 |
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| 作者姓名： | 王文君 王培训 粱瑞燕 |
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| 作者单位： | 广州中医药大学免疫学研究室,广州,510405;广州中医药大学免疫学研究室,广州,510405;广州中医药大学免疫学研究室,广州,510405 |
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| 摘 要： | 研究丹参酮对肥大细胞增殖凋亡以及活化脱颗粒的影响,深入探讨丹参酮的抗炎药理机制。应用细胞培养、流式细胞术等方法,观察丹参酮等药物对体外培养的RBL-2H3肥大细胞增殖凋亡以及活化脱颗粒的影响。结果:丹参酮I、IIA对肥大细胞增殖有明显的抑制作用,其IC50约为20μmol/L,并能明显促进细胞凋亡,且对RBL-2H3细胞活化脱颗粒有较强的抑制作用。结论:丹参酮对肥大细胞功能具有明显的抑制作用,可能是其发挥抗炎作用的一个重要方面。
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| 关 键 词： | 丹参酮 RBL-2H3肥大细胞 增殖 凋亡 脱颗粒 |
| 文章编号： | 1001-2478(2008)02-0132-04 |
| 修稿时间： | 2007-12-20 |
Effects of Tansinone on the proliferation, apoptosis, and degranulation of mast cells line RBL-2H3 |
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| WANG Wen-jun,WANG Pei-xun,LIANG Rui-yan. Effects of Tansinone on the proliferation, apoptosis, and degranulation of mast cells line RBL-2H3[J]. Current Immunology, 2008, 28(2): 132-135 |
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| Authors: | WANG Wen-jun WANG Pei-xun LIANG Rui-yan |
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| Abstract: | To explore the mechanism of anti-inflammatory effect of Tansicone,a monomer component extracted from Chinese medicine Salvia miltiorrhiza,the influence of Tansinone on the proliferation,apoptosis and degranulation of mast cell line RBL-2H3 was investigated by means of cell cultures and flow cytometry.It was found that Tansinone I and II showed inhibitory effect definitely on the proliferation of the mast cell line RBL-2H3 with a IC50 of about 20 μmol/L and they could obviously promote the occurrence of apoptosis in this cell line.In addition,they also exhhibited a strong inhibitory effect on the antigen-induced degranulation of mast cells.From these observations it suggests that the anti-inflammatory effect of Tanshinone may be partially due to the down-regulation mechanism in mast cells. |
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| Keywords: | Tanshinone RBL-2H3 cells proliferation apoptosis degranulation |
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