Neoadjuvant pegylated liposomal doxorubicin in combination with cisplatin and infusional fluoruracil (CCF) with and without endocrine therapy in locally advanced primary or recurrent breast cancer |
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Authors: | Rosalba Torrisi Emilia Montagna Eloise Scarano Silvia Dellapasqua Giuseppe Cancello Monica Iorfida Alberto LuiniPaolo Veronesi Giuseppe Viale Aron GoldhirschMarco Colleoni |
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Institution: | a Research Unit of Medical Senology, European Institute of Oncology, via Ripamonti 435 20141 Milano, Italy b Division of Senology, European Institute of Oncology, via Ripamonti 435 20141 Milano, Italy c Division of Pathology, European Institute of Oncology, via Ripamonti 435 20141 Milano, Italy d Department of Medicine, European Institute of Oncology, via Ripamonti 435 20141 Milano, Italy e University of Milan School of Medicine, via Festa del Perdono 7, 20135 Milano, Italy |
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Abstract: | PurposeTo explore the activity of pegylated liposomal doxorubicin (PLD) as neoadjuvant therapy of breast cancer.MethodsThe combination of PLD with cisplatin and infusional fluorouracil (CCF) for 8 courses was investigated in patients with primary or recurrent T2-T4a-d N0-3 M0 breast cancer. Patients with ER and/or PgR ≥10% tumors also received letrozole (±triptorelin).ResultsForty patients entered the study. Four patients had recurrent tumors and 13 had cT4d tumors. Overall, clinical response rate was 77.5% whereas a pathological complete response (pCR) was obtained in 3 patients (7.7%), 4 when considering bilateral tumors. Noticeably 3 pCR were observed among the 10 patients with T4d ER positive tumors (33%). Eleven patients discontinued treatment before completion of the 8 planned courses.ConclusionsOur results indicated that CCF yielded an appreciable rate of clinical responses in a series of very locally advanced tumors and an unusually high rate of pCR in T4d ER positive tumors, suggesting an enhanced cutaneous activity of PLD. |
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Keywords: | Pegylated liposomal doxorubicin Primary therapy Breast cancer Inflammatory breast cancer |
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