Quantitative elastography of renal transplants using supersonic shear imaging: a pilot study |
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Authors: | Nicolas Grenier Séverine Poulain Sébastien Lepreux Jean-Luc Gennisson Benjamin Dallaudière Yann Lebras Eric Bavu Aude Servais Vannary Meas-Yedid Mathieu Piccoli Thomas Bachelet Micka?l Tanter Pierre Merville Lionel Couzi |
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Affiliation: | Service d'Imagerie Diagnostique et Interventionnelle de l'Adulte, Centre Hospitalier Universitaire de Bordeaux, Université Bordeaux Segalen, 33076, Bordeaux, France, nicolas.grenier@chu-bordeaux.fr. |
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Abstract: | Purpose To evaluate the reliability of quantitative ultrasonic measurement of renal allograft elasticity using supersonic shear imaging (SSI) and its relationship with parenchymal pathological changes. Materials and methods Forty-three kidney transplant recipients (22 women, 21 men) (mean age, 51?years; age range, 18–70?years) underwent SSI elastography, followed by biopsy. The quantitative measurements of cortical elasticity were performed by two radiologists and expressed in terms of Young’s modulus (kPa). Intra- and inter-observer reproducibility was assessed (Kruskal-Wallis test and Bland-Altman analysis), as well as the correlation between elasticity values and clinical, biological and pathological data (semi-quantitative Banff scoring). Interstitial fibrosis was evaluated semi-quantitatively by the Banff score and measured by quantitative image analysis. Results Intra- and inter-observer variation coefficients of cortical elasticity were 20?% and 12?%, respectively. Renal cortical stiffness did not correlate with any clinical parameters, any single semi-quantitative Banff score or the level of interstitial fibrosis; however, a significant correlation was observed between cortical stiffness and the total Banff scores of chronic lesions and of all elementary lesions (R?=?0.34, P?=?0.05 and R?=?0.41, P?=?0.03,respectively). Conclusion Quantitative measurement of renal cortical stiffness using SSI is a promising non-invasive tool to evaluate global histological deterioration. Key Points ? Supersonic shear imaging elastography can measure cortical stiffness in renal transplants ? The level of cortical stiffness is correlated with the global degree of tissue lesions ? The global histological deterioration of transplanted kidneys can be quantified using elastography |
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