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| CD4+CD25+T细胞延长同种异体胰岛移植物存活 | |
| 引用本文： | 张梅,徐书杭,徐瑜,刘翠萍,茅晓东,徐宽枫,刘超. CD4+CD25+T细胞延长同种异体胰岛移植物存活[J]. 中华内分泌代谢杂志, 2008, 24(6) |
| 作者姓名： | 张梅 徐书杭 徐瑜 刘翠萍 茅晓东 徐宽枫 刘超 |
| 作者单位： | 1. 南京医科大学第一附属医院内分泌科,210029 2. 徐州矿务集团总医完内分泌科 3. 上海交通大学附属瑞金医院内分泌代谢病科 |
| 基金项目： | 江苏省政府医学重点学科项目 |
| 摘 要： | 探讨CD4+ CD25+调节性T细胞作为细胞疫苗抑制小鼠同种异体胰岛移植物排斥反应的作用,采用免疫磁珠分离技术分选CD4+ CD25+调节性T细胞联合BALB/cByJ小鼠同种异体胰岛移植.结果 显示,CD4+ CD25+调节性T细胞可明显延长同种异体移植物的存活时间. |
| 关 键 词： | T淋巴细胞,调节性 胰岛移植 免疫耐受 |
CD4+ CD25+ regulatory T cells prolong islet allografts survival |
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| ZHANG Mei,XU Shu-hang,XU Yu,LIU Cui-ping,MAO Xiao-dong,XU Kuan-feng,LIU Chao. CD4+ CD25+ regulatory T cells prolong islet allografts survival[J]. Chinese Journal of Endocrinology and Metabolism, 2008, 24(6) | |
| Authors: | ZHANG Mei XU Shu-hang XU Yu LIU Cui-ping MAO Xiao-dong XU Kuan-feng LIU Chao |
| Abstract: | The potential effect of donor CD4+ CD25+ regulatory T ceLls on the suppression of rejection for allogenetic islet transplantation in vivo was investigated. CD4+ CD25+ regulatory T cells were generated by magnetic activated cell sorting and were ailogeneically transfered with islet transplantation in streptozotocin-induced diabetic BALB/cByJ mice. The results showed that allogeneic CD4+ CD25+ regulatory T cells prolong islet graft survival and normoglycemia in transplanted allogeneic diabetic mice. |
| Keywords: | T-lymphocytes,regulatory Islets of Langerhans transplantation Immune tolerance |
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