A novel EBNA-1 titration method and putative anti-EBNA-1 protein |
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| Authors: | M Nonoyama L T Wen T Tabata A Tanaka |
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| Affiliation: | Department of Virology, Showa-Teikyo International Research Center, St. Petersburg, Florida 33716. |
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| Abstract: | A novel and rapid EBNA-1 titration method has been developed which uses immunoprecipitation of specific DNA-protein complexes with EBNA-1-positive serum. The method is more sensitive than the conventional immunofluorescence method and has potential value as a diagnostic reagent for clinical laboratories. TPA induction of putative anti-EBNA-1 protein of cellular origin is discussed, which may play a key role for the shift from latent to lytic replication of EBV. |
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