| 谷光甘肽转硫酶基因与急性白血病易感性的Meta分析 |
| |
| 引用本文： | 袁慧,王金权. 谷光甘肽转硫酶基因与急性白血病易感性的Meta分析[J]. 现代预防医学, 2004, 31(3): 322-323 |
| |
| 作者姓名： | 袁慧 王金权 |
| |
| 作者单位： | 皖南医学院预防医学教研室,芜湖,241000 |
| |
| 基金项目： | 安徽省高等学校青年教师科研资助计划 ( 2 0 0 3 jq14 0 )，皖南医学院中青年基金 ( WK2 0 0 2 0 7B) |
| |
| 摘 要： | 目的 :探讨谷光甘肽转硫酶 (GSTM1、 T1)基因多态性与急性白血病个体遗传易感性的关系。方法 :采用 Meta分析方法对筛选出的国内外相关的病例对照研究进行综合定量分析。结果 :GSTM1、 GSTT1基因缺失型及 M1- T1双重缺失型可增加急性白血病的危险性 ,其综合 OR值分别为 1.4 5 3、 1.4 18和 2 .5 35。结论 :GSTM1、 GSTT1基因缺失可能是急性白血病发生的危险因素之一。
|
| 关 键 词： | 基因多态性 谷光甘肽转硫酶 急性白血病 Meta-分析 |
| 文章编号： | 1003-8507(2004)03-0322-02 |
| 修稿时间： | 2003-09-26 |
META-ANALYSIS ON THE RELATIONSHIP BETWEEN GLUTATHION S-TRANSFERASE GENETIC POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE LEUKEMIA |
| |
| YUAN Hui,WANG Jin-quan.Departmemtal of Preventive Medicine of Wannan Medical college,Wuhu,.. META-ANALYSIS ON THE RELATIONSHIP BETWEEN GLUTATHION S-TRANSFERASE GENETIC POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE LEUKEMIA[J]. Modern Preventive Medicine, 2004, 31(3): 322-323 |
| |
| Authors: | YUAN Hui WANG Jin-quan.Departmemtal of Preventive Medicine of Wannan Medical college Wuhu . |
| |
| Affiliation: | YUAN Hui,WANG Jin-quan.Departmemtal of Preventive Medicine of Wannan Medical college,Wuhu,241000. |
| |
| Abstract: | Objective:To study the effect of glutathion S-transferase M1,T1 genetic polymorphism in the development of acute leukemia.Methods:The results of related studies from 1991 to 2002 were analyzed by the means of Meta-analysis.Results:The null genotype of GSTM1,T1 might increase acute leukemia risk.Conclusion:It suggests that individuals with GSTM1,T1 deletion might be susceptibility to acute leukemia. |
| |
| Keywords: | Genetic polymorphism Glutathion S-transferase Acute leukemia Meta-analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
