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40-Hz steady state response in Alzheimer's disease and mild cognitive impairment |
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| Authors: | JA van Deursen EFPM Vuurman VHJM van Kranen-MastenbroekFRJ Verhey WJ Riedel |
| Institution: | a Dept. of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands b Dept. of Neuropsychology & Psychopharmacology, Faculty of Psychology, Maastricht University, The Netherlands c Dept. of Clinical Neurophysiology, University Hospital Maastricht, The Netherlands |
| Abstract: | The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n = 15), subjects with mild cognitive impairment (MCI) (n = 20) and healthy elderly control subjects (n = 20). All participants were naïve for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown.The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression. |
| Keywords: | Alzheimer's disease MCI EEG 40-Hz Steady state response Cortical inhibition Reliability Neurophysiology |
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