乙肝病毒前S1抗原检测在入境人员检测诊断中的应用价值

目的评价乙肝病毒PreS1抗原在入境人员检测中的应用价值。方法将2008—2010年经我中心体检的362份入境乙肝病毒表面抗原(HBsAg)阳性的血清标本进行PreS1抗原检测,同时用PCR法进行乙型肝炎病毒基因(HBV-DNA)测定。结果PreS1总阳性率为41.16%,HBV-DNA阳性率为43.92%,乙肝病毒e抗原(HBeAg)阳性率为29.83%。PreS1总阳性率明显高于HBeAg阳性率。PreS1与HBV-DNA的总符合率为84.80%。结论PreSl抗原作为乙肝感染和复制的血清学指标敏感性高于HBeAg,对提示乙肝患者的病情发展和转归有重要临床意义。PreS1抗原可以作为一项新的乙肝病毒复制的指标在入境人员中进行筛查。

Significance of detecting PreS1 antigen of hepatitis B virus for entry personnel

Objective To evaluate the application value for detecting PreS1 antigen of hepatitis B virus （HBV） in the detection and diagnosis among entry personnel. Methods PreS1 antigen detection among the 362 samples of HBV surface antigen （HBsAg）-positive serum were detected from 2008 to 2010, and HBV-DNA by PCR was determinated. Results Total positive rate of PreS1 was 41.16%,the positive of rate HBV-DNA was 43.92%, the positive rate of HBeAg was 29.83%. The total positive rate of PreS1 was significantly higher than that of HBeAg. The coincidence rate of PreS1 and HBV-DNA was 84.80%. Conclusion As serology index of HBV infection and replication, the PreS1 antigen is more sensitive than HBeAg. And it is important clinical significance for indicating the progression and prognosis of patient with HBV. PreS1 antigen can he used as a new index HBV replication for entry personnel screening.