Asymmetries of the central sulcus in young adults: Effects of gender,age and sulcal pattern |
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| Institution: | 1. Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan 250012, Shandong, PR China;2. Shandong Medical Imaging Research Institute, Shandong University, Jinan 250021, Shandong, PR China;3. Xu Zhou Medical College, School of Medical Imaging, Department of Imaging Engineer, Xuzhou 221004, Jiangsu, PR China;4. Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, PR China;5. School of Computer Science and Technology, Tianjin University, Tianjin 300072, PR China;1. Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, Research Unit, Copenhagen University Hospital, Hellerup, Denmark;2. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;3. Department of Child and Adolescent Psychiatry, Copenhagen University Hospital – Psychiatry Region Zealand, Roskilde, Denmark;4. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark;5. Copenhagen Research Center for Mental Health – CORE, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark;6. Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark;7. Psychosis Research Unit, Aarhus University Hospital Psychiatry, Aarhus, Denmark;8. Department of Clinical Medicine, Faculty of Health and Medical Services, Aarhus University, Aarhus, Denmark;9. Division of Child and Adolescent Psychiatry, Department of Psychiatry, University Medical Center, University of Lausanne, Lausanne, Switzerland;10. Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark;1. Department of the Built Environment, Unit Building Physics and Services, Eindhoven University of Technology, Eindhoven, The Netherlands;2. Research Centre for Innovations in Health Care, Utrecht University of Applied Sciences, The Netherlands;1. School of Architecture and Urban Planning, Shadid Beheshti University, Tehran, Iran;1. Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, the Netherlands;2. Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands;3. Radiology, University Medical Center Utrecht, Utrecht, the Netherlands;4. Kate Gleason College of Engineering, Rochester Institute of Technology, NY, USA;5. Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium;6. Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany;7. Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, Ontario, Canada;8. C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands;9. Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway;10. Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands;11. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK;12. Department of Pharmacology, National University of Singapore, Singapore;13. Memory Aging and Cognition Center, National University Health System, Singapore;14. Saw Swee Hock School of Public Health, National University of Singapore, Singapore;15. Department of Intensive Care, University Medical Centre, Utrecht, the Netherlands;p. Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, Location Academic Medical Center, Amsterdam, the Netherlands;q. School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand;r. Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands;s. The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, Oslo University Hospital, Oslo, Norway;t. Sunnybrook Research Institute, University of Toronto, Toronto, Canada;u. Department of Medical Biophysics, University of Western Ontario, London, Canada;v. Imaging Division, Lawson Health Research Institute, London, Canada;w. Department of Pediatric Infectious Diseases, Emma Children’s Hospital, Amsterdam University Medical Centre, Location Academic Medical Center, Amsterdam, the Netherlands;x. Department of Neurology, Donders Institute for Brain, Behavior and Cognition, Radboud University Medical Centre, Nijmegen, the Netherlands;y. Neurology, Amsterdam University Medical Center, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands;z. Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;11. Fraunhofer MEVIS, Bremen, Germany;12. University of Bremen, Bremen, Germany;13. Mediri GmbH, Heidelberg, Germany;14. Institute of Biomedical Engineering, Department of Engineering Science & Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK;15. UCL Queen Square Institute of Neurology, University College London, London, UK;16. Department of Biomedical Engineering, School of Biomedical Engineering & Imaging Sciences, King’s College London, King’s Health Partners, St Thomas’ Hospital, London, SE1 7EH, UK;17. Department of Psychology, University of Oslo, Norway;18. Clinical Imaging Sciences Centre, Department of Neuroscience, Brighton and Sussex Medical School, Brighton, UK;19. Centre for Medical Image Computing (CMIC), Faculty of Engineering Science, University College London, London, UK |
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| Abstract: | In this study, we clarified the gender and age-related asymmetries of the central sulcus (CS) in early adulthood using a parametric ribbon method. The CS was reconstructed and parameterized automatically from 3D MR images of 112 healthy right-handed subjects. The 3D anatomic morphology of the CS was presented using 5 sulcal parameters, including sulcal depth position-based profile (DPP), average depth (AD), average width (AW), top length (TL) and bottom length (BL). Asymmetry differences in DPPs were found in the medial and lateral part of the CS. In addition, significant gender differences were observed in the medial and middle parts of the right CS DPPs but scattered in the left side. We found leftward asymmetries of TL in males, but rightward asymmetries of AW in females. Males had a greater AW than females in the right hemisphere. Moreover, the females had bilateral longer TL and a longer left BL than did males. We also found significant age-related reductions in bilateral TL and increases in bilateral AW, with males presenting more obvious age-related change than females. There were sexual differences of the CS patterns, in which Type b was the most dominant sulcal pattern in males, whereas Type a was dominant in females. Three-way ANOVA revealed sexual and asymmetry changes of TL and BL among different CS patterns. Our findings indicate that the lateralization performances of the CS manifest as sexually and regionally different. In addition, it is suggested that males may undergo a faster progress of aging compared to females. |
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| Keywords: | Central sulcus Gender dimorphism Asymmetry Age Sulcal pattern Magnetic resonance imaging |
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