Reliability and accuracy assessment of morphometric measurements obtained with software for three-dimensional reconstruction of brain aneurysms relative to cerebral angiography measures |
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Authors: | Pablo M Munarriz,Eduardo Bá rcena,Jose F Alé n,Ana M Castañ o-Leon,Igor Paredes,Luis Miguel Moreno-Gó mez,Daniel Garcí a-Pé rez,Luis Jimé nez-Roldá n,Pedro A Gó mez,Alfonso Lagares |
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Affiliation: | 1.Department of Neurosurgery, Hospital Universitario 12 de Octubre, Instituto de Investigación i±12, Madrid, Spain; 2.Department of Surgery, Universidad Complutense de Madrid, Madrid, Spain; 3.Department of Radiology, Hospital Universitario 12 de Octubre, Madrid, Spain; 4.Department of Neurosurgery, Hospital Universitario La Princesa, Madrid, Spain |
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Abstract: | ObjectiveTo analyze the reliability and accuracy of morphological measurements of software employed to three-dimensionally reconstruct aneurysms and vessels (VMTKlab, version 1.6.1,) with computed tomography angiography (CTA) as the source of images. Agreement with measurements from three-dimensional digital subtraction angiography (3 D-DSA) was evaluated.MethodsWe evaluated 40 patients presenting with aneurysmal subarachnoid hemorrhage (aSAH). We analyzed four main variables of the aneurysm morphology: absolute height (size), neck (maximum neck width), perpendicular height, and maximum width. The CTA images were uploaded to the software and then segmented to reconstruct the aneurysm. This new method was compared to the current gold standard—3D reconstruction of pretreatment cerebral angiography. We used intraclass correlation coefficient (ICC) and Bland-Altman plot analyses to evaluate the agreement between these methods.ResultsThe ICCs obtained for absolute height, neck, perpendicular height, and maximum width were 0.85, 0.57, 0.85, and 0.89, respectively. This implied good agreement except for the neck of the aneurysm (moderate agreement). Bland-Altman plots are presented for the four indexes. The average of the differences was not significant in terms of absolute height, perpendicular height, and maximum width indicating good agreement. However, it was significant for the neck of the aneurysm.ConclusionsWe report good agreement between the values generated using VMTKlab and cerebral angiography for three of the four main variables. Discrepancies in neck diameter are not surprising and its underestimation with a traditional delineation from cerebral angiography has been reported before. |
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Keywords: | Intracranial aneurysm cerebral angiography subarachnoid hemorrhage CFD computational geometry image segmentation mesh generation |
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