脑梗死患者急性期-康复期认知变化与脑MRI分析

血管性痴呆是医学研究的热点 ,关于血管性痴呆和脑ＣＴ的研究报告并不少见 ,但脑梗死急性期-康复期认知变化与ＭＲＩ的分析尚少报告。由于脑梗死无疑是血管性痴呆的主要原因 ,而且随着人口老龄化 ,伴有弥漫性、混杂性脑病变的急性脑梗死病人增多 ,急性期脑ＭＲＩ发现在认知障碍中的作用 ,以及在康复过程中与认知改变的相关性 ,有待研究探讨。现将我们的观察分析报告如下。1　资料和方法1.1　研究对象1999年 4月至 2 0 0 1年 4月在我院神经内科住院的浦东地区急性脑梗死患者 10 1例 ,男 5 4例 ,女4 7例 ,年龄 5 0～ 83岁 ,平均 6 7.2 7± 8.4…

Correlations between MRI and Cognitive Changes during Acute to Rehabilitation Phase of Cerebral Infarction

Objective: To examine correlations between MRI and cognitive changes associated with cerebral infarction. Methods: Using HDS-R and Senior Cognitive Scale, we assessed 101 patients with cerebral infarction during acute to rehabilitation phase. The results were compared with their MRI. Results: At 3 weeks after onset, cognitive impairment was found in 70.3% of the patients. At 6 months after onset, 10% recovered to normal, 35.6% improved, 22.8% worsened, and 42.5% met the criteria of dementia. During acute phase, infarction focus and leukoaraiosis (LA) were related to cognitive impairment ( P <0.05). During rehabilitation phase, cognitive impairment was related to LA.Conclusion:Cerebral infarction results in significant cognitive impairment. LA is the major cause of cognitive impairment associated with cerebral infarction in rehabilitation.