{gamma}{delta} T cells promote CD4 and CD8 expression by SCID thymocytes |
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Authors: | Lynch Felicity; Shevach Ethan M |
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Institution: | Laboratory of Immunology, National Institute of Aliergy and Infectious Diseases, National Institutes of Health Bethesda, MD 20892, USA |
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Abstract: | Molecular studies of the ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) TCR, which is expressed by a minorsubpopulatlon of T lymphocytes in all vertebrate species, havedefined a subset which expresses a receptor with extreme junctionaldiversity and a second subset, most commonly found in eplthella,which expresses a receptor of very limited diversity. In thedeveloping murine thymus, ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) T cells appear in an ordered sequenceof specific v rearrangements, V 3V , 1 on day 14, V 2V 1 on day17, and subsequently V 4V 5, V 6, or V 7. We demonstrate that thetransfer of expanded populations of ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) cells from newborn thymusand cell lines expressing the invariant V 3V 1 receptor into SCIDmice, which lack T and B cells, results in the appearance ofCD3–CD4+CD8+ thymocytes. Thus, one role of the early appearingV 3V 1 T cells in thymlc development in vivo is to promote CD4and CO8 surface expression on precursor cells. |
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Keywords: | dendritic epidermal T cells SCID mice thymus T cell development |
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