Imputabilité d’une mise en jeu du pronostic vital à un inhibiteur spécifique de la thrombine |
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Authors: | W Hanf J Duntze H Hida Q Blanc C Reynaud |
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Institution: | 1. Service de réanimation, CHG de Valence, boulevard du Maréchal-Juin, 26953 Valence cedex 9, France;2. Service de neurochirurgie, hôpital Maison-Blanche, 45, rue Cognacq-Jay, 51092 Reims cedex, France;3. Service de pharmacie, CHG de Valence, boulevard du Maréchal-Juin, 26953 Valence cedex 9, France |
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Abstract: | We present the case of a 73-year-old man, operated on for paralyzing sciatica, who displayed acute postoperative respiratory distress and intra-alveolar haemorrhage following the administration of dabigatran etexilate, a new oral antithrombin used in the prevention of venous thromboembolism. This serious incident occurred in a patient who had a 20-year history of chronic thrombocytopenia (platelet level at 100 G/l) and a heparin-induced thrombocytopenia and in whom no other aetiology was found (tuberculosis, pneumorenal syndrome, etc.). The postoperative prevention of thromboembolic events in a patient with high risk bleeding requires intensive monitoring, notably, when prescribing new drugs such as new anticoagulant agents. |
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Keywords: | Chirurgie du rachis Dabigatran etexilate Dé tresse respiratoire Hé morragie intra-alvé olaire Inhibiteur direct de la thrombine |
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