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儿童用药口感评价现存问题与发展思路浅析
引用本文:游龙泰, 张欢, 关玮伟, 梅冬, 王晓玲. 儿童用药口感评价现存问题与发展思路浅析[J]. 中国现代应用药学, 2023, 40(22): 3060-3065. DOI: 10.13748/j.cnki.issn1007-7693.20231944
作者姓名:游龙泰  张欢  关玮伟  梅冬  王晓玲
作者单位:1.国家儿童医学中心, 首都医科大学附属北京儿童医院药学部, 北京 100045
基金项目:北京市自然科学基金-海淀原始创新联合基金资助项目(L202048,L212013);北京市科技新星计划项目(Z201100006820009);中国药学会医院药学专业委员会医院药学人才专项资助项目-优秀人才项目(CPA-Z05-ZC-2021-003);首都医科大学附属北京儿童医院院企合作资助项目(基于人工智能的儿童面部表情分析系统)
摘    要:口感是影响口服制剂服药依从性的重要因素。儿童具有独特的病理、生理特征,对不良口感的耐受性差,导致服药剂量不准确,用药风险高。因此,建立客观、科学的口感评价方法,是儿童用药研发的重要环节,具有重要的临床意义和科学价值。本课题组从“仪器、研发、临床、审评、监管”5个维度,组织儿童用药口感设计与评价领域专家,结合中国儿童用药临床特点,明确现状,探讨问题,并提出改进思路,为开发适宜儿童的口服制剂提供参考。

关 键 词:儿童用药  口感  评价
收稿时间:2023-07-11
修稿时间:2023-10-20

Analysis of Current Issues and Improvement Strategies in the Taste Evaluation of Pediatric Medication
YOU Longtai, ZHANG Huan, GUAN Weiwei, MEI Dong, WANG Xiaoling. Analysis of Current Issues and Improvement Strategies in the Taste Evaluation of Pediatric Medication[J]. Chinese Journal of Modern Applied Pharmacy, 2023, 40(22): 3060-3065. DOI: 10.13748/j.cnki.issn1007-7693.20231944
Authors:YOU Longtai  ZHANG Huan  GUAN Weiwei  MEI Dong  WANG Xiaoling
Affiliation:1.National Center for Children's Health, Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
Abstract:Taste is an important factor influencing the efficacy of oral formulations and patient compliance. Children have unique pathological and physiological characteristics and poor tolerance to adverse taste, which leads to inaccurate dosing and high risk of medication administration. Therefore, the establishment of an objective and scientific taste evaluation method is an important part of the research and development of drugs for children, which has important clinical significance and scientific value. This research group organized experts in the field of taste design and evaluation of pediatric drugs from five dimensions: instrumentation, research and development, clinical, review, and regulation, to clarify the current situation, discuss problems, and propose strategies for improvement, so as to provide reference for the development of suitable oral formulations for children.
Keywords:pediatric medication  oral sensory feature  evaluation
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