Differential expression of epithelial cell adhesion molecule in salivary gland neoplasms |
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| Institution: | 1. Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand;2. Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand;1. Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK;2. The Gade Laboratory of Pathology, Department of Clinical Medicine, University of Bergen, Norway;1. Division of Oral Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951–8514, Japan;2. Division of Oral Pathology, Department of Oral Basic and Clinical Sciences, College of Dentistry, Taibah University, Medina 41311, Saudi Arabia;3. Oral Pathology Section, Department of Surgical Pathology, Niigata University Hospital, Niigata 951–8520, Japan;1. Fellow, Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Franz-Josef-Strauß-Allee, Regensburg, Germany;2. Senior Physician, Department of Pathology;3. Senior Physician, Department of Radiotherapy;4. Chairman, Department of Otorhinolaryngology;5. Chairman, Department of Oral and Maxillofacial Surgery;6. Deputy Chairman, Department of Oral and Maxillofacial Surgery |
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| Abstract: | Epithelial cell adhesion molecule (EpCAM) is the epithelial-specific molecule expressed on various epithelial cell types. The function of EpCAM involves cellular adhesion, proliferation, and signaling in both normal tissues and cancers. The purposes of this study were to investigate the EpCAM expression in salivary gland neoplasms and examine its relationship with pathologic characteristics. Forty-two cases of salivary gland neoplasms, including 20 mucoepidermoid carcinomas (MECs), 11 adenoid cystic carcinomas (ACCs), 9 pleomorphic adenomas (PAs), and 2 polymorphous low-grade adenocarcinomas (PLGAs) were enrolled. Epithelial cell adhesion molecule expression was analyzed immunohistochemically using MOC-31 and BerEP4 antibodies. Results showed that the majority of MECs and all PLGAs showed EpCAM expression in more than 50% of neoplastic cells, whereas most PAs and ACCs did not express this protein. In MECs, most EpCAM-positive neoplastic cells were clear cells, glandular epithelial cells, and intermediate cells, whereas squamous cells and mucous cells were largely negative. The expression was limited to ductal epithelium in EpCAM-positive PAs and ACCs. The decreased EpCAM expression in MECs was significantly associated with microscopically diminished cystic components, the presence of small nest invasion at invasive front, cellular anaplasia, vascular invasion, and high pathologic grade. These data suggested that EpCAM showed different expression pattern among salivary gland neoplasms and in different grades of MECs. |
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