| 有机锗对大鼠实验性矽肺形成及脂质过氧化水平的影响 |
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| 引用本文： | 王明臣,高琦,文春河. 有机锗对大鼠实验性矽肺形成及脂质过氧化水平的影响[J]. 郑州大学学报(医学版), 1995, 0(1) |
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| 作者姓名： | 王明臣 高琦 文春河 |
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| 作者单位： | 河南医科大学生物化学教研室，河南省职业病防治所 |
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| 摘 要： | 采用硫代巴比妥酸比色法和亚硝酸盐形成法，分别测定了实验性矽肺大鼠血清过氧化脂质（ＬＰＯ）及超氧化物歧化酶（ＳＯＤ）同工酶活力，同时观察了β羧乙基锗倍半氧化物（Ｇｅ－１３２）对实验性大鼠矽肺形成的阻断作用及对自由基代谢的影响。结果显示矽肺大鼠血清ＬＰＯ含量显著高于对照组，而血清总ＳＯＤ和ＣｕＺｎＳＯＤ活力显著下降。提示矽肺的发生可能与机体自由基代谢的失衡有关。使用Ｇｅ－１３２可显著提高大鼠机体的抗氧化能力，降低脂质过氧化作用，并可明显干预矽肺病变的形成。
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| 关 键 词： | 大鼠；矽肺；游离基类；过氧化脂质类；Ge－132 |
Effect of organic germaninum on the formation of silicosis and the lipid peroxide levels in experimental rats |
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| Wang Mingchen,Gao Qi,Wen Chunhe. Effect of organic germaninum on the formation of silicosis and the lipid peroxide levels in experimental rats[J]. Journal of Zhengzhou University: Med Sci, 1995, 0(1) |
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| Authors: | Wang Mingchen Gao Qi Wen Chunhe |
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| Abstract: | The serum LPO contents and SOD isozyme activities in the experimental rats with silicosis were determined with thiobarbituric acid colorimetry and nitrite formation method respectively. The blocking effect of carboxyethyl germaninum sesquioxide(Ge-132) on the formation of suicosis and the metabolism of free radical were also observed,The results showed that the serum LPO levels in rats with silicosis were higher than those of the control group(P<0. 01) and that the total serum SOD and CuZnSOD activities were significantly lower.These indicated that the occurrence of silicosis was possibly related with the metabolic imbalance of free radical.Ge-132 could obviously enhance the antioxidant effect and reduce the lipid peroxidation, and markedly interfere with the formation of silicosis lesions. |
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| Keywords: | rat silicosis free radical lipid peroxide Ge-132 |
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