扩散张量成像对健康成人腰椎间盘与年龄及解剖部位的相关性研究

目的用扩散张量成像(diffusion tensor imaging,DTI)探讨健康人腰椎间盘与年龄及解剖部位的相关性。材料与方法募集健康成人志愿者21~45岁共30名,分为21~25岁组、26~30岁组、31~35岁组、36~40岁组、41~45岁组共五组,进行DTI序列扫描,用磁共振ADW4.4软件测出每组的FA及ADC值。探讨以上数值与年龄的变化及不同节段间盘的相关性。结果随着年龄的增加,L1-S1间盘ADC值逐渐下降,(Ⅰ:r=-0.470,P0.01;Ⅱ:r=-0.513,P0.01;Ⅲ:r=-0.593,P0.01;Ⅳ:r=-0.697,P0.01;Ⅴ:r=-0.601,P0.01)FA值与年龄不相关。随着解剖节段的下移,在不同的腰间盘节段L1~4呈轻度下降,L4~S1明显增高,总体为上升趋势(F=8.726,P0.05)。结论 ADC值随着年龄的增长而下降,FA随着位置的下移而有增高趋势,下位间盘增高明显。DTI研究表明腰椎间盘的退行性改变与年龄及解剖部位均有相应关联。

The study of correlation between ageandanatomical segment in healthy lumbarinterverbraldiscs by diffusion tensor imaging

Objective: Discuss the correlation between lumbar intervertebral disc and age and anatomic site for healthy people with diffusion tensor imaging (DTI). Materials and Methods: Gather 30 healthy adult volunteers with their age range from 21 to 45, which are divided into 5 groups, 21—25, 26—30, 31—35, 36—40 and 41—45. Carry out DTI sequence scanning on them and determine FA and ADC value of each group with MRI software ADW 4.4. Discuss the correlation between above value and age change and different segments of intervertebral disc.Results:With the growth of age, ADC value of L1-S1 declines gradually (Ⅰ:r=-0.470,P<0.01,Ⅱ:r=-0.513, P<0.01,Ⅲ:r=-0.593, P<0.01,Ⅳ:r=-0.697, P<0.01,Ⅴ:r=-0.601, P<0.01), and FA value is not related to age. With the moving down of anatomic segment, at different sites, L1—4 declines slightly and L4—S1 rises obviously, as a whole, it presents a rising trend (F=8.726,P<0.05).Conclusions:ADC value declines with the growth of age. FA value presents a rising trend with the moving down of position and lower intervertebral disc rises obviously. The DTI study indicates that the degenerative change of lumbar intervertebral disc has the correlation with both age and anatomic site.