Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS‐13期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS‐13

Authors:	L. Deforche E. Roose A. Vandenbulcke N. Vandeputte H. B. Feys T. A. Springer L. Z. Mi J. Muia J. E. Sadler K. Soejima H. Rottensteiner H. Deckmyn S. F. De Meyer K. Vanhoorelbeke

Affiliation:	1. Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Kulak, Kortrijk, Belgium;2. Transfusion Research Center, Belgian Red Cross Flanders, Gent, Belgium;3. Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA;4. Departments of Medicine, Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA;5. Research Department 1, The Chemo‐Sero‐Therapeutic Research Institute, Kikuchi, Kumamoto, Japan;6. Baxter Innovations GmbH, Vienna, Austria

Abstract:

Keywords:	ADAMTS‐13 protein, human allosteric regulation autoantibodies protein conformation von Willebrand factor