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Expression of mouse Tbx2 gene in normal and malignant melanophores by RT-PCR
Authors:Bao-guo Liu  fang-qun Han  CR Goding
Affiliation:(1) Department of Surgical Oncology, Beijing Cancer Hospital; School of Oncology, Beijing Medical University, 100036 Beijing, China;(2) Marie Curie Cancer Research Institute, RH8 OTL Oxted, Surrey, UK
Abstract:Objective: To observe the expression of mouse Tbx2 gene in normal and malignant melanophore. Methods: The normal and malignant cells were used to extract total RNA. The expression of the Tbx2 gene was detected by RT-PCR. Results: No expression of the Tbx2 gene in the normal melanocytes was noted, but all malignant cells showed expression of the Tbx2 gene. Conclusion: Tbx2 plays a critical role during the development of the malignant cells.
Keywords:Gene amplification   Gene expression   Malignant cell   Tbx2
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