血清内毒素定量检测在慢性乙型肝炎患者中的应用

目的探讨血清内毒素定量检测在慢性乙型肝炎住院患者中的应用价值。方法 采用BET-24A细菌内毒素分析仪对中南大学湘雅医院60例慢性乙型肝炎住院患者及15例健康体检者血清标本进行内毒素定量测定,并结合是否有合并自发性腹膜炎等临床资料,进行综合分析。结果慢性乙型肝炎患者血清内毒素检测值高于健康体检者,差异有统计学意义（P〈0.05）;其中合并有自发性腹膜炎的慢性乙型肝炎患者血清内毒素检测值高于其他慢性乙型肝炎患者,差异有统计学意义（P〈0.05）。结论慢性乙型肝炎患者常常合并有内毒素血症,其中合并有自发性腹膜炎患者内毒素血症更明显,预后更差。BET-24A细菌内毒素分析仪能够简单、快速、准确检测出结果,具有临床实用价值,值得推广。

Application of Quantitative Measuring Endotoxin in Patients with Chronic Hepatitis B

Objective To explore the application value of quantitative measurement of endotoxin in the inpatients with chronic hepatitis B(CHB). Methods The serum endotoxin was quantitatively detected in 60 inpatients with CHB and 15 healthy physical examinees who were all from Xiangya Hospital by BET-24A bacterial endotixin analyzer.The comprehensive analysis was made by combining with the clinical data and whether the CHB patients were complicated with spontaneous peritonitis. Results The value of endotoxin concentration in CHB patients was higher than that in healthy physical examinees,and the difference showed statistically significant(P<0.05).The value of endotoxin concentration in CHB patients who were complicated with spontaneous peritonitis were higher than that in CHB patients who were not,and the difference was statistically significant(P<0.05). Conclusions CHB patients were frequently complicated by endotoxin.Endotoxin was even obvious and prognosis was worse in CHB patients who were complicated by spontaneous peritonitis.Using BET-24A bacterial endotixin analyzer can simply,rapidly,and accurately detect endotoxin in serum.It is valuable in clinical practice and worthy of being developed further.