| 益气养阴解毒方对非小细胞肺癌患者T细胞亚群及Th1/Th2漂移的影响 |
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| 引用本文： | 梁芳,张勇,李朝衡,曹海涛.益气养阴解毒方对非小细胞肺癌患者T细胞亚群及Th1/Th2漂移的影响[J].实用中医内科杂志,2011,25(5):8-10. |
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| 作者姓名： | 梁芳 张勇 李朝衡 曹海涛 |
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| 作者单位： | 1. 上海中医药大学附属普陀医院,上海,200062
2. Texas College of TCM,Austin,TX,78704 |
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| 摘 要： | 目的]观察益气养阴解毒方对晚期非小细胞肺癌患者的临床疗效及其对T细胞亚群、Th1/Th2漂移的影响,进一步探讨益气养阴解毒方治疗肺癌的部分作用机制。方法]采用前瞻性的随机对照方法,将45例中医辨证为气阴两虚型的晚期非小细胞肺癌患者随机分为两组,治疗组以化疗结合益气养阴解毒方加减治疗,对照组单纯化疗,化疗均采用NP(诺维本+顺铂)方案,2个周期后进行疗效判定。结果]治疗组咳嗽、咯痰、食欲不振、口干咽噪、神疲乏力等症状及气阴两虚证候的改善率、体重及卡氏评分的改善率方面均优于对照组(P<0.05);局部瘤灶的疗效评定显示,治疗组的有效率和疾病控制率略高于对照组(P>0.05);治疗组能升高CD3+T细胞、CD4+T细胞的比率及CD4/CD8比值(P<0.05);降低CD8+T细胞的比率(P>0.05);治疗组治疗后IL-2水平明显升高(P<0.05),IL-10水平有下降的趋势(P>0.05);治疗组能有效降低IL-10/IL-2比值(P<0.05)。结论]益气养阴解毒方能够稳定瘤灶,改善临床症状,提高肺癌患者的生存质量,具有良好的临床疗效;同时该方能够有效调节机体的细胞免疫功能;能够通过调节细胞因子的分泌影响Th1/Th2漂移,可能为益气养阴解毒方治疗肺癌的作用机制之一。
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| 关 键 词： | 肺癌 中医药治疗 Th1/Th2漂移 |
Effect of Yiqi Yangyin Jiedu Formula on T-Cell Subsets and Shifting of Th1/Th2 Balance in NSCLC Patients |
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| Authors: | LIANG Fang ZHANG Yong LI Chao-heng CAO Hai-tao |
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| Institution: | LIANG Fang1,ZHANG Yong1,LI Chao-heng1,CAO Hai-tao2(1.Tumor Depart.,Putuo Hospital Affiliated to Shanghai University of TCM,Shanghai 200062,China,2.Texas College of TCM,Austin,TX,78704) |
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| Abstract: | Objective]To observe therapeutic effect of Yiqi Yangyin Jiedu Formula treating NSCLC Patients as well as effect on T cell subsets and shifting of Th1/Th2 balance.Mechanism of this formula was also discussed.Methods]Prospective and random study methods were used.The total of 45 patients were divided into two groups which are chemo group and chemo with herb group.Therapeutic effect was evaluated two weeks later.Results]Treatment group was much better than control group in improving symptoms,body weight and... |
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| Keywords: | lung cancer TCM treatment shifting of Th1/Th2 balance |
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