厄贝沙坦联合胺碘酮对高血压合并阵发性心房颤动的疗效

目的 探讨厄贝沙坦联合胺碘酮治疗高血压合并阵发性心房颤动(PAF)的临床疗效.方法 将74例高血压合并PAF患者按随机数表法分为试验组和对照组,每组37例.试验组采用厄贝沙坦+胺碘酮治疗,对照组采用硝苯地平+胺碘酮治疗.治疗12个月后对2组患者的降血压(SBP、DBP)水平、心房颤动(AF)复发率、窦性心律维持率、左心房内径(LAD)变化进行比较.结果 2组患者均随访12个月,在随访中对照组3例、试验组2例患者因甲状腺功能异常、转氨酶升高退出研究.2组患者治疗后血压较治疗前均有明显下降(均P＜0.05);试验组治疗前后与对照组比较差异无统计学意义(均P＞0.05).试验组中6例(17.1%)患者发生心电图证实的AF发作,对照组中13例(38.2%)发生心电图证实的AF发作,2组比较差异有统计学意义(P＜0.05).试验组治疗后窦性心律维持率为82.9%,对照组窦性心律维持率为61.8%,2组比较差异有统计学意义(P＜0.05);试验组治疗后LAD为(37.0±3.6)mm,对照组LAD为(38.9±3.3) mm,试验组LAD显著小于对照组(P＜0.05).结论 厄贝沙坦联合胺碘酮治疗高血压合并PAF能有效地控制血压,预防PAF的复发,对延缓左心房扩大有一定的作用.

Curative Effect of Irbesartan Combined with Amiodarone on Hypertension Complicated by Paroxysmal Atrial Fibrillation

Objective To discuss the curative effect of Irbesartan combined with Amiodarone on hypertension complicated by paroxysmal atrial fibrillation(PAF).Methods A total of 74 patients with hypertension complicated by PAF were randomly assigned to receive either irbesartan plus amiodarone(experimental group,n=37) or Nifedipine plus Amiodarone(control group,n=37).The depressurization(SBP,DBP)level,relapse rate of atrial fibrillation(AF),maintenance rate of sinus rhythm and left atrial diameter(LAD) were compared be...