动态脉压对老年高血压病患者左心室肥厚及主动脉根部扩张的影响

目的研究老年高血压病患者动态脉压(24 h PP)与左心室肥厚(LVH)及主动脉根部(AOD)扩张的相关关系。方法对60例老年高血压病患者进行动态血压(ABP)和超声心动图等检查,分别测量ABP和超声心动图的各种参数。将24 h PP≥60 mm Hg(1 mm Hg=0.133 kPa)的患者30例作为A组,24 h PP<60 mm Hg的患者30例作为B组。结果A、B两组LVH和AOD扩张的发生率差异有显著性意义(P<0.01)。左心室重量指数与24 h PP2、4 h平均收缩压(24 h SBP)密切相关(P<0.01),与脉压和收缩压呈正相关(P<0.05)。AOD与24 h PP、24 h SBP、年龄和病程密切相关(P<0.01)。结论老年高血压病患者的24 h PP与LVH及AOD扩张密切相关,24 h PP可作为评价抗高血压药物能否更好地减少高血压病患者靶器官损害的重要指标之一。

Effect of ambulatory pulse pressure on left ventricular hypertrophy and enlarged diameter of aortic root in aged hypertensives

Objective To find out the relationship between ambulatory pulse pressure(24 h PP) and left ventricular hypertrophy(LVH) and the enlarged diameter of aortic root(AOD) in aged patients with essential hypertension.Methods Sixty aged patients with essential hypertension were divided into group A(24 h PP≥60 mm Hg) and group B(24 h PP<60 mm Hg)according to the 24 h PP.All patients in both groups received examinations such as ambulatory blood pressure(ABP) and echocardiography,and the correlations were analyzed between the ABP and left ventricuIar mass index(LVMI) and AOD.Results The prevalence of LVH and enlarged AOD was signiticantly higher in group A than in group B(all P<0.01).Significant correlation existed between the LVMI and 24 h PP or 24 h SBP(r=0.46 and 0.42 respectively) and positive correlation existed between LVMI and PP or SBP(r=0.33,0.31 respectively,P<0.05 each).Similarly,there was significant correlation between the AOD and 24 h PP,24 h SBP,PP,SBP,age or course of disease(r=0.49,(0.40),0.40,0.32,0.25 and 0.30 respectiyely,P<0.01 each).Conclusion The 24 h PP is closely correlated with LVH and enlarged AOD in aged patients with essential hypertension.