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Effect of aging on vulnerability of striatal D1 And D2 dopamine receptor-containing neurons to kainic acid |
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| Authors: | Liang Zhang James A Joseph George S Roth |
| Institution: | aMolecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA;bDepartment of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong;cUSDA ARS HNRCA at Tuft's University, 711 Washington Street, Boston, MA 02111, USA |
| Abstract: | Kainic acid lesions elicit reductions in ligand binding to both D1 and D2 striata dopamine receptors in young and old rats. Relative reductions are greatest for both receptors in young animals than old. In addition, D1 receptor binding is reduced more than D2 at both ages. These findings support the idea that those dopamine receptor neurons lost during aging may reside in a kainic acid sensitive population. |
| Keywords: | Aging D1 and D2 dopamine receptors Kainic acid |
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