| 应用基因芯片技术研究大鼠妊娠期胰岛基因表达谱的变化 |
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| 引用本文： | 薛莹,刘翠萍,袁庆新,徐宽枫,徐瑜,茅晓东,陈国芳,刘超.应用基因芯片技术研究大鼠妊娠期胰岛基因表达谱的变化[J].中华内分泌代谢杂志,2008,24(6). |
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| 作者姓名： | 薛莹 刘翠萍 袁庆新 徐宽枫 徐瑜 茅晓东 陈国芳 刘超 |
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| 作者单位： | 1. 江苏省苏北人民医院内分泌科工作
2. 南京医科大学第一附属医院内分泌科,210029 |
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| 摘 要： | 利用基因芯片技术研究大鼠妊娠不同阶段胰岛基因表达谱的变化.与正常对照组相比,大鼠妊娠期数百条基因发生差异表达,其中基因Reg3α在孕期表达显著高于正常对照组,可能与胰岛再生相关.
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| 关 键 词： | 妊娠 基因表达 寡核苷酸序列分析 胰岛再生 |
Application of microarray technique in gene expression analysis of pancreatic islets in pregnant rats |
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| XUE Ying,LIU Cui-ping,YUAN Qing-xin,XU Kuan-feng,XU Yu,MAO Xiao-dong,CHEN Guo-fang,LIU Chao.Application of microarray technique in gene expression analysis of pancreatic islets in pregnant rats[J].Chinese Journal of Endocrinology and Metabolism,2008,24(6). |
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| Authors: | XUE Ying LIU Cui-ping YUAN Qing-xin XU Kuan-feng XU Yu MAO Xiao-dong CHEN Guo-fang LIU Chao |
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| Abstract: | Genechip was applied to explore gene expression profile of islets in rats at various stages of pregnancy. Compared with the normal control group, differential expressions of hundreds of genes were detected during pregnancy. Reg3α gene expression was markedly increased during pregnancy, which may be related to islet regeneration. |
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| Keywords: | Pregnancy Gene expression Oligonucleotide array sequence analysis Islet regeneration |
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