| 肝动脉栓塞微球的动物药动学和药效学研究 |
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| 引用本文： | 陈庆华. 肝动脉栓塞微球的动物药动学和药效学研究[J]. 中国药师, 1998, 1(1): 3-5 |
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| 作者姓名： | 陈庆华 |
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| 作者单位： | 上海医药工业研究院 200437 |
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| 基金项目： | 国家七五攻关项目，八五攻关项目 |
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| 摘 要： | 肝动脉栓塞微球是用于治疗中晚期肝癌的新剂型。通过动脉插管即可将微球栓塞肝癌邻近的末梢动脉血管,起阻断血流和在局部缓释药物的双重作用。本文结合几年来对甲氨蝶吟(MTX),羟基喜树碱明胶微球和顺铂-乙基纤维素微球的基础研究工作,综述微球栓塞后在动物的体内过程和药效学。
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| 关 键 词： | 肝动脉栓塞微球 体内过程 疗效 |
Study of Pharmacokinetic and Pharmacodynamics of Microspheres for Hepatic Arterial Embolization in Animals |
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| Cheng Qinghua. Study of Pharmacokinetic and Pharmacodynamics of Microspheres for Hepatic Arterial Embolization in Animals[J]. China Pharmacist, 1998, 1(1): 3-5 |
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| Authors: | Cheng Qinghua |
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| Affiliation: | Cheng Qinghua Shanghai Institute of Pharmaceutical Industry,Shanghai 200437,P.R.China |
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| Abstract: | The microsphere for hepatic arterial embolization is a new dosage form in the treatment of non-resectable liver cancer. Through the ultra-selective cathter, the microspheres could be sent to the ending vessels of hepatic artery nearthe cancer, resulting from the double effects-the blood stream blocked and the drug release locally slowly. In combinationof the basic research on MTX, hydroxy-camptothecine gelatin microspheres, and cisplatin-ethyl cellulose microspheres in past years, their behavior in vivo and the pharmacodynamics in treatment of liver cancer after arterial embolization in animals were reviewed briefly. |
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| Keywords: | Microspheres for hepatic arterial embolization behavior in vivo curative effect |
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