男性冠心病患者血清睾酮水平及其临床意义

目的测定男性冠心病（CHD）患者血清性激素水平,探讨其临床意义。方法因胸痛行冠状动脉造影的男性患者115例,根据造影结果分为CHD组和对照组。冠脉病变程度由病变总积分表示。采用化学发光免疫法（CLIA）测血清睾酮（T）和雌二醇（E2）水平。结果（1）CHD组T水平显著低于对照组（t=3.15,P〈0.01）;剔除糖尿病患者,校正年龄、体重指数和低密度脂蛋白胆固醇的影响后,CHD组T水平仍显著低于对照组（F=6.11,P〈0.01）。（2）血清T水平与病变积分、年龄、体重指数呈负相关（r=-0.28,P〈0.01;r=-0.24,P=0.01;r=-0.26,P〈0.05）。（3）低血清T水平、高胆固醇血症和老龄是冠心病发病的危险因素。结论（1）男性CHD患者血清T水平降低。（2）T水平随冠脉病变程度加重而下降,并随年龄和体重指数的增加而降低。（3）T水平降低可能是男性CHD发病的危险因素。

Chemiluminesent immunoassay determined the level of serum testosterone in men with coronary heart disease andits clinical significance

Objective To determine the level of serum sex hormone in male with coronary heart disease（CHD） and observe its clinical significance.Methods 115 men underwent coronary angiography were distributed into CHD group and control group.The severity of coronary artery lesion was evaluated by cumulative scores of lesion.The serum testosterone（T） and estradiol（E2） were examined by the Chemiluminesent immunoassay.Results （1）Men with CHD had significantly lower level of serum T（t=3.15,P〈0.01） than control group.Excluding the patients with DM,the level of T between two groups still had obvious difference after controlling for age,BMI and LDL-C（F=6.11,P〈0.01）.（2）The level of T was negatively correlated with the scores of lesion,age,BMI （r=-0.28,P〈0.01;r=-0.24,P=0.01;r=-0.26,P〈0.05）.（3）Logistic analysis show low serum T level,age and high TC were risk factors of male CHD.Conclusions （1）The male patients with CHD had significantly lower serum T level.（2）The serum T level was negatively correlated with the degree of coronary artery lesion,age,BMI.（3）A low serum T level may be a risk factor for male CHD.