Salmonella enterica serovar Typhimurium ompS1 and ompS2 mutants are attenuated for virulence in mice |
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| Authors: | Rodríguez-Morales Olivia Fernández-Mora Marcos Hernández-Lucas Ismael Vázquez Alejandra Puente José Luis Calva Edmundo |
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| Affiliation: | Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, México. |
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| Abstract: | Salmonella enterica serovar Typhimurium mutants with mutations in the ompS1 and ompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator of ompS2, was also attenuated. |
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