非编码RNA与血脂代谢的研究进展

 冠心病的主要病理学基础是动脉粥样硬化，其发生发展是多因素、多步骤的，也是遗传和环境因素交互作用的结果。除年龄、性别、肥胖、吸烟、高血压、糖尿病等因素外，血脂代谢异常是促进动脉粥样硬化发生发展的重要因素。越来越多的证据表明非编码RNA参与调控过程，在血脂代谢和动脉粥样硬化的形成过程中发挥重要作用，特别是使用小干扰RNA（small interfering RNA，siRNA）从RNA水平调控血脂的RNA干扰（RNA interfering，RNAi）技术，不仅在动物实验上获得了明显的降脂效果，而且在临床试验上也取得了明显疗效。本文从非编码RNA的水平总结血脂代谢的影响因素及相关干预手段。

Research progress on non-coding RNA and blood lipid metabolism

Atherosclerosis is the main pathological basis of coronary heart disease.It is a complicated progress involved many factors,and the result of the interaction between genetic and environmental factors.In addition to factors such as age, gender, obesity,smoking,hypertension and diabetes,abnormal lipid metabolism is a particularly important factor in promoting the development of atherosclerosis.Nowadays,there is increasing evidence that non-coding RNA is involved in the regulation process and plays an important role in the lipid metabolism and formation of atherosclerosis.Especially,the RNA interference (RNAi) using small interfering RNA (siRNA) has achieved significant lipid-lowering effects not only in animal experiments,but also in clinical trials.This article reviewed influencing factors of lipid metabolism and related interventions on non-coding RNA level.