Taking the kidney to heart

• Growing evidence supports the role of Impella in the prevention of acute kidney injury in high‐risk percutaneous interventions (HR‐PCIs).
• The Mehran contrast‐induced nephropathy risk score may serve as a helpful risk stratification tool in discerning patients undergoing HR‐PCI who may benefit from renal protection with Impella support.
• Further research is warranted to validate this renal protection strategy.