埃兹蛋白和上皮型钙黏蛋白在肾透明细胞癌的表达及意义 |
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引用本文: | 吴文峰,辛军,伍伯聪,辛明华,黄志扬,倪建华,陈培煌. 埃兹蛋白和上皮型钙黏蛋白在肾透明细胞癌的表达及意义[J]. 现代医药卫生, 2010, 26(18): 2731-2733 |
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作者姓名: | 吴文峰 辛军 伍伯聪 辛明华 黄志扬 倪建华 陈培煌 |
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作者单位: | 福建医科大学附属泉州第一医院泌尿外科,福建,泉州,362000 |
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摘 要: | 目的:探讨埃兹蛋白(Ezrin)和上皮型钙黏蛋白(E-cadherin)在肾透明细胞癌及癌旁正常肾组织中的表达及与肿瘤侵袭、转移的关系.方法:采用免疫组织化学Elivision方法检测45例肾透明细胞癌组织及相应癌旁正常肾组织中Ezrin和E-cadherin的表达情况.结果:45例癌组织Ezrin异常表达率84.4%(38/45),癌旁正常肾组织Ezrin异常表达率40%(18/45),Ezrin在癌组织中的异常表达明显高于癌旁正常肾组织(χ2=18.9,P<0.005);45例癌组织E-cadherin异常表达率73.3%(33/45),癌旁正常肾组织E-cadherin异常表达率35.6%(16/45),E-cadherin在肾透明细胞癌中的异常表达明显高于癌旁正常肾组织(χ3=12.9,P<0.05);两者呈负相关;Ezrin和E-cadherin的表达与淋巴结转移、静脉瘤栓形成有关(P<0.05),与患者年龄、性别、肿瘤大小、病理分期无相关性(P>0.05).结论:Ezrin和E-cadherin与肾透明细胞癌的浸润转移有关,可能作为预测肾癌转移和判断预后的肿瘤标志物.
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关 键 词: | 肾透明细胞癌 埃兹蛋白 上皮型钙黏蛋白 |
Expressions and significance of Ezrin and E-cadherin in clear cell renal cell carcinoma |
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Affiliation: | WU Wen-feng,XIN Jun,WU Bo-cong,et al.(Department of Urology,Affiliated Quanzhou First Hospital,Fujian Medical University,Quanzhou,Fujian 362000,China) |
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Abstract: | Objective:To explore the relationship between Ezrin and E-cadherin and clinical pathological parameters,tumor metastasis by detecting the expression of Ezrin and E-cadherin in clear cell renal cell carcinoma tissues and normal tissues adjacent to the cancer.Methods:Using immunohistochemistry to detect the expressions of Ezrin and E-cadherin in clear cell renal cell carcinoma tissues and the normal tissues adjacent cancer.Results:The expression of ezrin protein showed a significant difference between the clear cell renal cell carcinoma(84.4%,38/45) and the adjacent normal renal tissues(40,18/45)(χ^2=18.9,P〈0.05).The abnormal expression of E-cadherin protein was significantly higher in the clear cell renal cell carcinoma (73.3% ,33/45) than that in adjacent normal renal tissues (35.6%,16/45)(χ^2=12.9,P0.05).The correlation between the expression of Ezrin and E-cadherin is significant.The peotein expression of Ezrin and E-cadherin were correlated with lymph node involvement,venous tumor thrombus extention (P〈0.05).There was no correlation between the expression of Ezrin and E-cadherin and the age,gender,size and TNM stage of renal cell carcinoma (P〈0.05).Conclusion:Ezrin and E-cadherin are closely related with invasion and metastasis of clear cell renal cell carcinoma,which may be used as markers to predict metastasis and prognosis of the disease. |
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Keywords: | Clear cell renal cell carcinoma Ezrin E-cadherin |
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