Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood |
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| Affiliation: | 1. Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 511400, China;2. School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China;1. Division of Pediatric Allergy and Asthma Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Sıhhiye, Ankara, 06100 Turkey;2. Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Turkey;1. Faculdade das Ciências da Vida, Universidade da Madeira, Portugal;2. Sociedade Portuguesa de Alergologia e Imunologia Clínica - SPAIC, Lisboa, Portugal;3. Instituto de Ciências Agrárias e Ambientais Mediterrânicas – ICAAM, Évora, Portugal;4. Centro de Imunoalergologia do Algarve, Portimão, Portugal;5. Allergy Center, CUF Descobertas, Lisbon, Portugal;1. Universidade de Passo Fundo (UPF) and Faculdade Meridional (IMED), Passo Fundo, Rio Grande do Sul (RS) and Chief of Allergy, Clinical Immunology, Department of Pediatrics Allergy and Immunology Pediatric at Universidade Federal da Fronteira Sul (UFFS), Brazil;2. Clinical Immunology and Rheumatology, Department of Pediatrics, Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), São Paulo, SP, Brazil;3. Epidemiologist of the GPPG at the Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil;4. Universidade Federal da Fronteira Sul (UFFS), Passo Fundo, RS, Brazil;5. Faculdade Meridional (IMED), Passo Fundo, RS, Brazil;6. Pneumology Division at the HCPA – UFRGS, Porto Alegre, RS, Brazil;1. Clinical and Chemical Pathology Department, National Research Center, Egypt;2. Molecular Genetics and Enzymology Department, National Research Center, Egypt;3. Pediatric Department, Cairo University, Egypt;1. Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Department of Pediatric Allergy and Immunology, University of Health Sciences, Ankara, Turkey;2. Faculty of Medicine, Department of Pediatric Allergy and Immunology, Mugla Sitki Kocman University, Mugla, Turkey |
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| Abstract: | Background and objectivesVitamin D status may be related to allergen sensitizations, but the evidence is inconsistent. The objective of this study was to assess whether serum 25-hydroxyvitamin D (25(OH)D) levels were associated with allergic sensitizations in early childhood.MethodsData were collected from 2642 children who visited the Guangdong Women and Children’s Hospital from January 2016 to May 2017 for routine health check-ups. Serum 25(OH)D levels were tested by electrochemiluminescence immunoassay. Allergic sensitizations including food and inhalant allergens were tested for specific IgE antibodies at one year (12 months 0 days through 12 months 30 days) and two years (24 months 0 days through 24 months 30 days) of age.ResultsThe mean level of serum 25(OH)D was 86.47 ± 27.55 nmol/L, with a high prevalence of vitamin D insufficiency (<75 nmol/L) in children aged 0–2 years (36.8%). Lower 25(OH)D levels with serum total IgE of more than 200 IU/mL (81.54 ± 25.53 nmol/L) compared with less than 100 IU/mL (87.92 ± 28.05 nmol/L). The common sensitization to allergens in children aged one and two years were milk (44.2%), cat epithelium (26.4%), egg (13.1%), dog epithelium (12.7%) and Dermatophagoides farinae (6.7%). After multivariate adjustment, data in 25(OH)D treated as a continuous variable or categories, no consistent associations were found between 25(OH)D levels and allergen-specific IgEs.ConclusionsSerum 25(OH)D level showed an inverse relationship with total IgE level in early childhood. However, there is lack of evidence to support associations between low 25(OH)D levels and allergic sensitization to various allergens. |
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| Keywords: | Allergy Allergic sensitization Vitamin D |
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