Phenotypical characterization of tree nuts and peanut allergies in east Mediterranean children |
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| Affiliation: | 1. Division of Pediatric Allergy and Asthma Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Sıhhiye, Ankara, 06100 Turkey;2. Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Turkey;2. Sheffield Children’s Hospital NHS Foundation Trust, Sheffield, UK;3. King’s College Hospital NHS Foundation Trust and MowatLabs, London, UK;5. University of Nicosia, Cyprus;1. Department of Otolaryngology, Affiliated ZhangJiaGang Hospital of Soochow University, Suzhou, 215600, China;2. Institute of Translational Medicine, Affiliated ZhangJiaGang Hospital of Soochow University, Suzhou, 215600, China;3. School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, 325003, China;4. Jiangsu University Health Science Center, Zhenjiang, Jiangsu Province, 212001, China;1. Dresden International University, Division of Health Care Sciences, Center for Clinical Research and Management Education, Dresden, Germany;2. Hospital Medica Sur, Mexico City, Mexico;3. Laboratorio de Alergia Molecular, Mexico City, Mexico;4. Allergy and Immunology, Department of Pediatrics, New York University Langone Health, New York, NY, USA;5. Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland;6. Medica Sur Clinical Foundation and Hospital, Mexico City, Mexico |
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| Abstract: | Introduction/ObjectivesThe characteristics of tree nuts (TNs) and peanut (PN) allergies vary in different regions of the world. We aim to identify the characteristics of TNs/PN allergies in Turkish children.Patients and MethodsA total of 227 children [4.8 (3.2–6.8) years] with TN and/or PN allergies were included. The phenotypical features of TNs/PN allergic children and the risk factors for multiple TNs/PN allergies were evaluated.ResultsAllergy to TNs/PN developed at a median age of 12.0 (10.0–18.0) months. The most common TNs/PN responsible for food allergies were the hazelnut (63.9%) and the pistachio (54.6%). Of TNs/PN allergic children, 54.2% experienced reactions with at least two types of . Current ages 6–10 years [OR:2.455, 95% CI:1.255-4.852, p = 0.009] and family history of atopy [OR:2.156, 95% CI:1.182–3.932, p = 0.012] were the risk factors for multiple TNs/PN allergies. Most of the patients with cashew nut and pistachio allergies exhibited co-sensitization and co-allergy to both of these TNs/PN. Although the rarest TNs/PN allergy was seen with almond, the possibility of allergy to other TNs or PN was highly increased in the patients with almond allergy compared to other TNs/PN.ConclusionsChildren with TNs/PN allergy living in an East Mediterranean region differ from the counterparts living in Western countries by an earlier age of onset of the TNs/PN allergy symptoms, increasing possibility to have multiple TNs/PN allergy at older ages, and different spectrum of TN/PN allergies (hazelnut followed by pistachio/cashew) that all indicate the consumption habits which are important determinants of TN/PN allergy development. |
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| Keywords: | Children Co-allergy Co-sensitization Peanut Tree nuts |
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