Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci |
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| Authors: | Diekema Daniel J Andrews Janet I Huynh Holly Rhomberg Paul R Doktor Stella R Beyer Jill Shortridge Virginia D Flamm Robert K Jones Ronald N Pfaller Michael A |
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| Institution: | Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA. daniel-diekema@uiowa.edu |
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| Abstract: | Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS. |
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