| 家族性乳腺癌患者BRCA1基因序列突变分析 |
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| 引用本文： | 孔灵玲,崔文,王旭,姜小刚,张国安.家族性乳腺癌患者BRCA1基因序列突变分析[J].济宁医学院学报,2011,34(2):96-98. |
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| 作者姓名： | 孔灵玲 崔文 王旭 姜小刚 张国安 |
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| 作者单位： | 济宁医学院基础医学与法医学院,山东,济宁,272067 |
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| 摘 要： | 目的 研究山东济宁地区家族性乳腺癌(familiar breast cancer,FBC)患者BRCA1基因的突变情况.方法 选取山东济宁地区8个乳腺癌家系中各1例乳腺癌患者,10例乳腺导管内乳头状瘤病例为对照.应用PCR技术和DNA直接测序技术检测BRCA1基因外显子11的突变.结果 实验组与对照组在外显子11的序列...
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| 关 键 词： | BRCA1 家族性乳腺癌 突变 |
Analysis of the mutations of BRCA1 in familiar breast cancer patients |
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| KONG Ling-ling,CUI Wen,WANG Xu,et al.Analysis of the mutations of BRCA1 in familiar breast cancer patients[J].Jounal of Jinning Medical College,2011,34(2):96-98. |
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| Authors: | KONG Ling-ling CUI Wen WANG Xu |
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| Institution: | KONG Ling-ling,CUI Wen,WANG Xu,et al(College of Basic and Forensic Medicine,Jining Medical University,Jining 272067,China) |
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| Abstract: | Objective To analyze the mutations of BRCA1 in familiar breast cancer patients of Jining.Methods Peripheral blood samples were obtained from 8 patients enrolled from 8 breast cancer families and 10 breast intraductal papillomatosis as control group.The mutations of BRCA1 gene exon11 were screened by the Polymerase Chain Reaction(PCR) and DNA sequencing.Results The mutation was not found in exon11 among these 8 familiar breast cancer patients and control group.Conclusion The mutation frequency of BRCA1 in fa... |
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| Keywords: | BRCA1 |
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