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| 1,25-二羟维生素D3联合塞莱昔布对乳腺癌细胞株HS578T增殖的影响 | |
| 引用本文： | 何雪琦,史志涛,鲍扬漪. 1,25-二羟维生素D3联合塞莱昔布对乳腺癌细胞株HS578T增殖的影响[J]. 济宁医学院学报, 2011, 34(1): 17-19. DOI: 10.3969/j.issn.1000-9760.2011.01.006 |
| 作者姓名： | 何雪琦 史志涛 鲍扬漪 |
| 作者单位： | 1. 济宁医学院临床学院,山东,济宁,272067 2. 济宁医学院附属医院,济宁,272029 3. 合肥市第一人民医院,安徽,合肥,230000 |
| 基金项目： | 合肥市科技局重点立项项目 |
| 摘 要： | 目的 研究1,25-二羟维生素D3[1,25(OH)2D3]联合塞莱昔布对乳腺癌细胞株HS578T生长的影响.方法 采用四唑氮蓝比色(MTT)法检测细胞增殖,免疫组化法检测Ki-67表达变化.结果 10-7mol/L、10-8mol/L的1,25(OH)2D3及塞莱昔布(50μmol/L)均可抑制乳腺癌细胞增殖,呈时间... |
| 关 键 词： | 1,25-二羟维生素D3 塞莱昔布 乳腺肿瘤 细胞增殖 |
The effect of combined treatment of 1,25(OH)_2D_3 and Celecoxib on the growth of breast cancer cell line HS578T |
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| HE Xue-qi,SHI Zhi-tao,BAO Yang-yi. The effect of combined treatment of 1,25(OH)_2D_3 and Celecoxib on the growth of breast cancer cell line HS578T[J]. Jounal of Jinning Medical College, 2011, 34(1): 17-19. DOI: 10.3969/j.issn.1000-9760.2011.01.006 | |
| Authors: | HE Xue-qi SHI Zhi-tao BAO Yang-yi |
| Affiliation: | HE Xue-qi,SHI Zhi-tao,BAO Yang-yi(Clinical Department,Jining Medical University,Jining 2720067,China) |
| Abstract: | Objective To study the effects of combined 1,25-dihydroxyvitamin D3[1,25(OH)2D3]and Celecoxib on the proliferation in breast cancer cell line HS578T.Methods We compared cell numbers by using MTT method,The expression of Ki-67 was detected by immunohistochemical method.Results Incubation with 10-7mol/L and 10-8mol/L1,25(OH)2D3,Hs578T cells exhibited significant growth inhibition,The immunohistochemical staining showed that the expression rate of Ki-67 protein was down-regulated in any treatemnt group compare... |
| Keywords: | 1 25-dihydroxyvitaminD3 Celecoxib Breast cancer Cell proliferation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |