| 依托红霉素颗粒含量测定的探讨 |
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| 引用本文： | 王和协,董帮兴,刘红,汪玉萍,林国红. 依托红霉素颗粒含量测定的探讨[J]. 安徽医药, 2009, 13(7): 746-747 |
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| 作者姓名： | 王和协 董帮兴 刘红 汪玉萍 林国红 |
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| 作者单位： | 安徽省安庆市药品检验所,安徽,安庆,246000;安徽省安庆市ATG医务室,安徽,安庆,246001 |
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| 摘 要： | 目的采用紫外分光光度法测定依托红霉素颗粒中红霉素的含量。方法根据红霉素在酸性条件下水解后，水解产物在482nm波长处有最大吸收的特点，对依托红霉素颗粒进行紫外分光光度法测定，并与微生物法测定方法比较。结果本法平均回收率为99．9％，RSD为0．6％（n=5）；样品含量测定结果与微生物法比较，无显著性差异（P〉0．05）。结论本法缩短了检验周期，快速，适用于该制剂的快速含量测定。
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| 关 键 词： | 依托红霉素颗粒 含量测定 探讨 |
Determination of erythromycin estolate granwles |
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| WANG He-xie,DONG Bang-xing,LIU Hong,WANG Yu-ping,LIN Guo-hong. Determination of erythromycin estolate granwles[J]. Anhui Medical and Pharmaceutical Journal, 2009, 13(7): 746-747 |
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| Authors: | WANG He-xie DONG Bang-xing LIU Hong WANG Yu-ping LIN Guo-hong |
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| Affiliation: | 1. Anqing Institute for Drug Control Anqing 246000 ;2. Anqing ATG Medical Office Anqing 246001 ) |
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| Abstract: | Aim To determine erythromycin estolate granules by wring ultraviolet spectrophotometric method.Method Based on the fact that after acidic condition hydrolisis,the hydrolysate has the biggest absorption characteristic at the 482 nm wavelength,estolats granwles were determined by erythromycin ultraviolet spectrophotometric method,and was compared with the microorganism law determination method.Result This average recovery rate was 99.9%.RSD was 0.6%(n=5).There is no significant difference between the two meth... |
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| Keywords: | erythromycin estolate granules determination discussion |
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