CYTOPLASMIC INCLUSIONS AND VIRUS-LIKE PARTICLES IN BLAST CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA |
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| Authors: | Tokuhiro Ishihara Noboru Matsumoto Yoshimi Yamashita Mutsuo Takahashi Fumiya Uchino Masamitsu Inoue Shigeru Yano Hiroyuki Tanaka Kenji Shinohara Toshio Kaneko |
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| Affiliation: | Department of Pathology, Yamagucki University School of Medicine, Ube;*The School of Allied Health Sciences, Yamaguchi University, Ube;**Department of Internal Medicine, Yamaguchi University School of Medicine, Ube |
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| Abstract: | Cytoplasmic inclusions and virus-like particles are described in blast cells of peripheral blood from a 16-year-old female with acute lymphoblastic leukemia. Three kinds of inclusions were identified on electron microscopy. The first type of inclusion was single membrane-bounded vacuoles, some of which contained virus-like particles, the second was lysosome-like structures, and the third appeared to be of mitochondrial origin. Virus-like particles were round in shape and had a diameter of 26 to 58 nm. They consisted of an electrondense outer membrane and an electron-lucent core. At the present time the exact nature and significance of these virus-like particles still remain unclear. |
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